Molecular Formula | C10H10N2O2 |
Molar Mass | 190.2 |
Density | 1.27±0.1 g/cm3(Predicted) |
Boling Point | 436.4±37.0 °C(Predicted) |
Flash Point | 169.064°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 5.73±0.40(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.628 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 5.258 ml | 26.288 ml | 52.576 ml |
5 mM | 1.052 ml | 5.258 ml | 10.515 ml |
10 mM | 0.526 ml | 2.629 ml | 5.258 ml |
5 mM | 0.105 ml | 0.526 ml | 1.052 ml |
Application | Ethyl 1H-pyrrolo [2,3-B] pyridine-2-carboxylate is an important raw material in organic synthesis, its derivative pyrrolopyridine-2-carboxylic acid amide is a glycogen phosphorylase inhibitor, which is used to prevent or treat diabetes, hypertension, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, atherosclerosis or tissue ischemia, and can be used as a cardioprotective agent. |
preparation | with 3-methyl-2-nitropyridine as raw material, by Reissert synthesis method, the reaction gave 1H-pyrrolo [2,3-B] pyridine-2-carboxylic acid ethyl ester. Alternatively, 2-bromo-3-pyridinecarboxaldehyde and ethyl cyanoacetate are used as starting materials to prepare the target compound 1H-pyrrolo [2,3-B] pyridine-2-carboxylic acid ethyl ester by cyclization reaction. The synthesis reaction formula is as follows: |